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boidinii is transmitted from seeds to leaves during early plant development, depending on its methanol utilization, enabling the yeast to establish residency on emerging leaf surfaces (Figures 1AC)

It produces anti-inflammatory cytokines including IL-10 and IL-13 to reduce inflammation and promote tissue growth (135)

Russnes KM, Mller E, Wilson KM, Carlsen M, Blomhoff R, Smeland S, et al

Studies using the 6-OHDA model of PD, which induces dopaminergic neuronal cell loss and motor symptoms in rats or mice, demonstrated activation of the NLRP3 inflammasome and the release of inflammatory cytokines, akin to what is observed in human PD [238]

Together with naringin, the use of poncirin from Poncirus trifoliata extract seems to exert antidepressant effects in mice by restoring vascular endothelial cell integrity in the hippocampus and controlling the neuroinflammatory responses of microglia at the Cornu Ammonis 1 (CA1) and dentate gyrus (DG) regions of the hippocampus [178]