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The NK1-Met interaction is believed to be physiologically relevant, because a therapeutic antibody against Met (onartuzumab) competitively inhibits the binding of NK1 fragment to Met 10

If the gut microbiome is altered, it might influence this process

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GO enrichment analysis suggested that the autophagy-related upregulated DEGs were enriched in pathways closely related to the cell cycle, cell proliferation, antioxidant stress, and energy metabolism functions, whereas the downregulated genes were enriched in pathways related to infection, immune defense, and chemical signaling

doi: 10.1016/j.neulet.2013.07.026 64 ValjentEBieverAGangarossaGPuighermanalE