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Deep-rooted dietary preferences Dietary cultures across different regions are deeply rooted in traditional foods, such as white rice in Asia and red meat and dairy products in Europe and North America [142]

doi: 10.1371/journal.pone.0033546 32 CoqueiroA

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Additionally, because of the short half-life and poor stability of conventional drugs, pharmacotherapy inevitably requires intensive dosing regimens, leading to a treatment burden, poor patient compliance, and even the discontinuation of treatment