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Most evidence is from animal studies, and large human trials are missing

These vary in the strength and consistency of supporting evidence, so it is useful to distinguish between the better-established findings and those representing a more preliminary evidence base

Early intervention can drastically reduce the risk of serious complications such as foot ulcers, infections, and Charcot foot deformity

In addition, hydroxocobalamin may be used as part of the treatment for cyanide poisoning (as an antidote), although in such emergency cases very high doses are administered under hospital care

If you have pernicious anemia, you'll have more trouble creating new blood cells and will require vitamin B12 supplementation