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Leucine, a key amino acid from a signaling point of view, is an allosteric activator of GDH, inducing the production of -ketoglutarate and preventing GLS inhibition by glutamate accumulation [38]

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Meanwhile, epigallocatechin gallate (EGCG), used alone or together with GLP-1 agonist exendin-4, was shown to enlarge islet area and number, expand -cell area, and boost pancreatic insulin content in diabetic and obese mouse models, thus demonstrating favorable therapeutic outcomes (Nupur et al., 2018)

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