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Studies have found that coffee may help lower the risk for some forms of cancer, including breast, colorectal, and liver cancers

[35] Although the mechanism is not very clear, the polyglutamylation of methotrexate and dihydrofolate in malignant cells is considered to play an important role in the selective reactivation of dihydrofolate reductase by folinic acid in normal cells

Sci Rep (2020) 10(1):16257

B., Radnai, B., Vmos, E., Kajner, G., Galbcs, G., Telek, E., Mszros, M., Deli, M

The HTS Core has been supported in part by the State of Colorado Office of Economic Development and the Colorado Clinical and Translational Sciences Institute (NIH Grant UL1TR001082), the University of Colorado Anschutz Medical Campus