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95 CFE has also been used to both express chaperones and subsequently assess their impact on folding of a target protein, a strategy that could accelerate researchers ability to identify the chaperones required for a given protein

In the rumen, these carbohydrates are rapidly fermented into short-chain fatty acids (SCFA) and lactate, leading to the accumulation of these acids and a decrease in ruminal pH below normal fermentation levels (i.e., pH 4 mmol/L after 24 h of ingestion of carbohydrates (7, 62), this becomes even more severe in calves, with concentrations exceeding 10 mM (31)

Lee DH, Han DH, Nam KT et al (2016) Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis

doi: 10.1016/j.cmet.2015.09.028

Proper reconstitution and dosing guidance are essential for safe and effective treatment