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Factors such as the highly acidic gastric environment (pH 1.03.0), enzymatic degradation by gastrointestinal digestive enzymes, and the barrier properties of the gastrointestinal mucosa insignificantly reduce drug bioavailability ( FIGURE 1 2.1.1 NDDS developed based on low stomach pH There were significant pH gradients in different anatomical parts of the digestive tract

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[DOI] [PMC free article] [PubMed] [Google Scholar] 886.Yang T., Yang B., Yin J., Hou C., Wang Q