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Indeed, unlike other thiols, homocysteine incubation with endothelial cells induces an increased expression of the stress protein GRP78 and a decreased expression of glutathione peroxidase, a major intracellular antioxidant enzyme, through a mechanism that depends on an alteration of the intracellular redox potential (Kokame et al, 1996

Activated PERK, phosphorylates eukaryotic initiation factor 2 (elF2) leading to cell cycle arrest and upregulates important transcription factors (ATF4, CHOP and Nrf2)

10.1182/blood.v94.10.3315.422k16_3315_3324 75 NezM

doi: 10.1007/s12104-018-9846-z Robinson, Samuel D., Mueller, Alexander, Clayton, Daniel, Starobova, Hana, Hamilton, Brett R., Payne, Richard J., Vetter, Irina, King, Glenn F