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doi: 10.1007/DCR.0b013e31819d1319 16 Foxx-OrensteinA

Given the high susceptibility of the brain to oxidative stress 40 , neurons require high levels of GSH to counteract oxidative stress and sustain cellular integrity and circuit function 58

Additionally, 4-Octyl itaconate (4OI) suppresses endothelial ferroptosis by activating the Kelch-like ECH-associated protein 1 (Keap1)/Nrf2/GPX4 signaling pathway [89]