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Due to this unique amino acid composition, combined with a high percentage of hydrophobic amino acids (19%), certain protein sequences in gluten are highly resistant to degradation by human gastrointestinal proteases [16,17], including pepsin, trypsin, chymotrypsin, carboxypeptidases A and B, elastases and enzymes of the small intestinal brush-border membrane

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However, this was resolved 3 h post-stress indicating that the neurons could compensate to clear the aberrantly accumulated TDP-43 within this acute stress paradigm

These findings underscore a global trend of underdiagnosed and undertreated DPN, necessitating a paradigm shift in healthcare strategies, robust awareness campaigns, and the implementation of comprehensive screening protocols to address this overlooked burden in patient care

10.1038/ncomms14240PubMed Abstract | CrossRef Full Text | Google Scholar 64 IyanagiT