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Mechanistically, hypoxic/glycolytic tumor niches boost glucose metabolism in CD71 + neutrophils, leading to increased lactate production and subsequent histone lactylation, but not histone acetylation, at the Arg1 promoter, resulting in T cell suppression

On the other hand, copper at supraphysiological concentrations can induce oxidative damage and apoptosis through ROS generation via the Fenton reaction, while simultaneously triggering cuproptosis by targeting mitochondrial proteins (He et al., 2024

Compared with Whites, there were not significant differences in all-cause mortality among Hispanics (OR 1.54, 95%CI: 0.97-2.45), Blacks (OR 1.13, 95%CI: 0.43-2.42), and Native Americans (OR 2.41, 95%CI: 0.42-13.73)