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Furthermore, mTOR inhibitors potently promote T-cell unresponsiveness, i.e., the diminished or loss of T-cell responsiveness to antigenic stimuli, in both in vitro and in vivo experiments (226, 227), which provides strong support for the reduction of rejection in contexts requiring immunosuppression, such as after organ transplantation

doi: 10.1007/s12031-021-01959-8 4 AbuaishS.Al-OtaibiN

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