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Pregnant mice were injected with LPS on E7.5 [17], followed by LBNP-PC@M administration from E11.5 to E13.5

the secondary C3-amine derivative intermediate e.g., compound 9) may then be methylated to obtain the desired cation (e.g., compound 1f)

Pilot experiments were conducted involving various models of rat peripheral nerve injuries (sham, nerve gap, crush injury, transection and repair) to confirm reproducibility of data

Do not take T4 within 4 hours of taking other medication

Laboratory and animal models consistently demonstrate that the pentadecapeptide enhances functional and biomechanical recovery following severe crush injuries, myotendinous tears and systemic tissue degeneration