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doi: 10.1038/nrg.2016.154

What Would Change This View A negative RCT in living skin If a properly powered randomized trial of at-home microinfusion with GHK-Cu versus matched topical control failed to show histologic or photographic differences at 12 weeks, that result would shift the position of this article from "biologically plausible recommendation" to "interesting hypothesis pending data." A safety signal in long-term at-home users If the consumer at-home microinfusion category began producing case reports of infection, scarring, or persistent dermal damage at rates higher than baseline microneedling, the depth recommendation would tighten or the route would be deprecated

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This equated 136 nurse consultations for maintenance therapy and 18 consultations for induction therapy, an annual total of 154 nurse consultations per year

In the present study, exogenous GSH enhanced JA signal transduction by inhibiting the expression of genes related to the JAZ protein, thus increasing the levels of JA