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Furthermore, the translocation to the plasma membrane of 78-kDa glucose-regulated protein GRP78, which facilitates M2 macrophage polarization of TAMs and tumor growth in lung cancer, was induced by IGF-1R signaling, and concomitant IGF-1 blockade and GRP78 knockdown in TAMs suppressed M2 macrophage-induced maintenance, proliferation, and migration of lung cancer cells (27)

Keto diets are also associated with diarrhea, constipation, bloating and nausea

Sun S, Liu D, Jiao Z

Meal and beta-alanine coingestion enhances muscle carnosine loading

doi: 10.1126/scitranslmed.aay1809, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] Zhao J., Fu Y., Yamazaki Y., Ren Y., Davis M