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There is still only a limited number of studies that have attempted to uncover the mechanisms governing necroptosis in erythrocytes, but there is evidence that necroptotic signaling in erythrocytes requires pore formation, necrosome assembly, NADPH oxidase- and Fenton chemistry-derived ROS, glucose-derived advanced glycation end products, ceramide, and Syk-mediated Band 3 protein phosphorylation [17, 198,199,200,201]