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Although they all result in lysosomal or protein degradation as a means of quality control, they are different in mechanism [21, 22]

The correlation coefficient (CC) of 9 in the two different conformations is in the 0.670.71 range, close to the CCs of the FAD cofactor in each subunit (CC = 0.730.74)

In addition, GSTs are also involved in conferring multidrug resistance with a non-catalytic mechanism through their inhibition of the JNK signaling pathway, an event that protects tumoral cells from apoptosis, as it will be detailed later

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A population of cells with stem cell properties (glioblastoma stem cells, GSCs) drives the initiation and progression of GBM and is localized in specialized microenvironments which support their behavior