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Neuroimaging studies have shown a reduction in hippocampal volume and abnormal prefrontal cortical activity, which strongly correlates with impairments in verbal memory and information processing speed ( 2.3.2 Psychiatric symptoms METH abuse disrupts the functionality of various brain regions, including the prefrontal cortex, nucleus accumbens, and thalamus, leading to significant psychiatric disturbances (Sekine et al., 2001)

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Notably, clinical trial involving the use of Daratumumab and Atezolizumab (anti-PDL1) (NCT03023423) was also halted due to the lack of clinical efficacy ( 5 Conclusions Despite the small sample size, this study has important clinical implications in the treatment of NKTL patients

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