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That being said, all four of the following leaf varieties play a role in influencing a cigar's strength level, with the mildest being at the bottom of the plant and the strongest sitting right at the top

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CS-induced hypoxia may play a role in mediating this as previous studies showed that CS stimulates hypoxia-related signalling in airway cell models 52,53 which is a known activating pathway for receptor-mediated mitophagy/autophagy 54,55,56,57,58,59