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Additionally, due to the accumulation of GalCer at the cytoplasmic leaflet, the ER adopts a rolled-up configuration

ROS can activate these kinases, leading to altered gene expression and promoting oncogenic transformation [106]

For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors Access this article Similar content being viewed by others Data Availability The datasets used and analyzed during the current study are available from the corresponding author upon reasonable request

This platform was developed utilizing unbiased weighted gene co-expression network analysis (WGCNA) from PHH microarray data obtained from an open data repository, TG-GATES