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4.2 Tumor microenvironment 4.2.1 Tumor-associated fibroblasts In CRC mouse models, it was shown that TGF- elevation in the tumor microenvironment confers resistance to anti-PD-1 therapy via inhibition of T-cell infiltration and decreased levels of type 1 T-helper cell phenotype (94)

Pro- and anti-inflammatory cytokines and POP IL-1 A recent single-cell examination of the uterosacral ligament (USL) revealed cellular heterogeneity in female POP patients