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Accumulated HS disrupts the lysosomal multienzyme complex of NEU1 with cathepsin A, -galactosidase (GLB1), and glucosamine-6-sulfate sulfatase (GALNS), leading to NEU1 deficiency and partial GLB1 and GALNS deficiencies in cortical tissues and induced pluripotent stem cell-derived (iPSC-derived) cortical neurons of patients with neurological MPS

Initially, both monomer 1 ( f = 1.1 ns) and 1 NF ( f = 0.4 ns) could only be found extracellularly, not inside E

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