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differences in protease activity between individuals can affect how quickly Melanotan II is broken down

[PubMed] Pierre S, Chevallier A, Teixeira-Clerc F, Ambolet-Camoit A, Bui LC, Bats AS, Fournet JC, Fernandez-Salguero P, Aggerbeck M, Lotersztajn S, Barouki R, Coumoul X (2014) Aryl hydrocarbon receptor-dependent induction of liver fibrosis by dioxin

Evidence Boundary: Although A/B-level studies show that this endpoint depends on the microbiota and is related to changes in metabolites, the existing evidence is not enough to determine the direction of barrier repair in the causal chain (upstream drive or downstream accompaniment)

In one population study, people with sleep apnea were found to have about 1.7-fold higher risk of experiencing vertigo than those without sleep apnea

SIBO Small intestinal bacterial overgrowth (SIBO), in particular methane dominant SIBO, sometimes called intestinal methanogen overgrowth (IMO), contributes to constipation by interfering with normal digestion and gut motility