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4.2 Anti-inflammatory effect 4.2.1 Validation of classical inflammatory models The principle of the carrageenan-induced inflammation model and the operation of the cotton ball implantation granuloma model are two classical animal experimental models commonly used to evaluate the anti-inflammatory activity of substances (especially drugs)

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The manufacturer discontinued both formulations in 2008 for business reasons, and a 2013 Federal Register determination confirmed the withdrawal was not for reasons of safety or effectiveness

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Metabolic phenotyping For the glucose tolerance tests, mice were fasted for 2 h (beginning at ZT0) and then administered glucose via oral gavage (2.5 g kg 1 body weight)