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To unbiasedly interrogate the impact on cancer cells of shifting from cystine-driven to GSH-driven cysteine supply, we performed a multifunctional approach to pharmacological screening (MAPS) with a library of 240 metabolic inhibitors (Fig

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This work was supported by grants from the NIH/NCI (R37-CA230042) to G.M.D, the Ludwig Center at Harvard to I.S.H., the AACR-Takeda Oncology Lung Cancer Research Fellowship (19-40-38-KANG) to Y.P.K., a National Pancreas Foundation grant to C.J

There, it undergoes a two-step proteolytic cleavage by site-1 protease (S1P) and S2P