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Systemically, iron is absorbed primarily in the duodenum, where it enters intestinal epithelial cells via DMT1

Similarly, the extent to which mitochondrial ultrastructural damage is a cause or consequence of energetic failure remains unresolved ( Looking forward, future research should prioritize large-scale, longitudinal studies that incorporate multi-omics profiling (transcriptomics, metabolomics, and imaging) to define patient-specific metabolic signatures ( 5 Therapeutic strategies targeting mitochondrial and fatty acid metabolism Pharmacological agents, natural products, traditional herbal formulations, gene and cell therapies, and lifestyle interventions have all been explored for their ability to restore mitochondrial function, optimize FAO, and improve cardiac energy homeostasis