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PARK2+E mice had significantly lower expression of Cpt1a (0.73 0.03 SEM), Cpt1c (0.86 0.02 SEM), Nrf2 (0.78 0.07 SEM), Pgc1 (0.82 0.3 SEM), Iba1 (0.85 0.3 SEM) and Gfap (0.84 0.03 SEM) compared to PARK2+V ( Cpt1a 1 0.05 SEM, p = 0.004, Cpt1c 1 0.04 SEM, p = 0.04, Nrf2 1 0.5 SEM, p = 0.03, Pgc1 1 0.4 SEM, p = 0.01, Iba1 1 0.05 SEM, p = 0.03, Gfap 1 0.5 SEM, p = 0.04) (Fig

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Comparison of the maximum respiration for the acylcarnitine ester relative to the equivalent FFA demonstrated that C6 and C8 are significantly more readily oxidized in the free form in the liver, whereas acylcarnitine esters from 12 to 18 carbons long were significantly more readily oxidized than the corresponding free forms (Fig

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Es un antioxidante eficaz que inhibe la accin de los radicales libres