glutathione peroxidase trace element Proposed catalytic mechanism of glutathione

Female: WT N = 8, cKO N = 8) for 9-days

doi: 10.3390/pathophysiology29030039 40 KanczkowskiWBeuschleinFBornsteinSR

While iron and transferrin have been shown to induce hepatic stellate cell activation and collagen expression in vitro [86,87,88], in vivo models of iron overload demonstrate only minor fibrosis, although the numbers of alpha-smooth muscle actin (SMA)-positive myofibroblasts were significantly increased [89, 90]

Glutathione Biochemistry Accumulating lines of evidence indicate that glutathione function is implicated in some neurodegenerative diseases such as Alzheimers disease, Parkinsons disease, ALS, Huntingtons disease, and Multiple Sclerosis

Alharbi TS, Alshammari ZS, Alanzi ZN, Althobaiti F, Elewa MA, Hashem KS, Al-Gayyar MM