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Higher doses may require multiple injections or more concentrated reconstitutions

La accin especfica del pptido sobre los adipocitos que expresan NNMT permite una modificacin metablica localizada sin una sobreestimulacin sistmica generalizada, lo que representa un modelo nico para estudios de modulacin selectiva de la masa grasa

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While clinical development for obesity was discontinued in 2007 after a Phase IIb trial failed to achieve its primary endpoint, the peptide remains a valuable research tool for investigating adipose tissue biology, lipolytic pathways, and receptor-independent signaling mechanisms

Deficiency has also been linked with a higher likelihood of pre-eclampsia, gestational diabetes and excess weight gain during pregnancy