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Collagen, a key structural protein in the skin, is particularly susceptible to glycation, which leads to its stiffening and impaired function

Discussion It has been estimated that 30 million people in the United States are affected by type 2 diabetes mellitus (T2DM), with an additional 80 million in the early stage of pre-diabetes

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Importantly, MSCs can also modulate the senescence-associated secretory phenotype (SASP) that characterises the post-chemotherapy ovarian stroma, reducing fibrosis and re-establishing a permissive niche for residual follicles [26, 27]

Different compounds such as UB-312 [213, 214], PD01A [215], and PD03A [216] have been developed and tested in Phase 1 trials