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doi: 10.3389/froh.2025.1564838 84 VilelaA.FerreiraL.BiscaiaP.da SilvaK.BeltrameF.CamargoG.et al

Concerns about glucose metabolism effects were not substantiated in clinical trials - despite GH's known acute insulin-antagonistic properties, CJC-1295 did not produce clinically significant hyperglycemia or impaired glucose tolerance in healthy subjects or patients studied, likely because the gradual and pulsatile nature of GH elevation differs from acute GH boluses that can cause transient insulin resistance