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J Exp Bot 65(5):12591270

Hydrates & nourishes

114 The density of AMPA, NMDA and P2X receptors as well as the density of plasmalemmal glutamate transporter currents demonstrates bell-shaped age dependency, with maximal densities observed in adult animals, whereas ageing is accompanied by a 2-3 fold decrease of density of respective ion currents

In fish, phagocytic immune cells like macrophages recognise ENMs as foreign invaders and attempt to clear them, a process that can trigger the release of pro-inflammatory cytokines and further ROS production (a respiratory burst).122,123,137,141 While this is a protective response, chronic, unresolved inflammation, or frustrated phagocytosis by fibrous ENMs, can lead to tissue damage and fibrosis