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Pteridines , 1989 , 1 , 65-70

This ROSImmune Mismatch, shaped by tumor redox heterogeneity and the differential oxidative sensitivities of immune subsets, represents a central barrier to effective cancer immunotherapy

ROS can induce mutations in the BRCA1 gene, which is involved in DNA repair, leading to impaired DNA damage response and increased susceptibility to tumorigenesis [100]