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Studies reviewed by Hector and Burton involving 91 patients with hypovitaminosis B12 who exhibited neuropsychiatric symptoms found that clinical improvement was achieved in many individuals through vitamin B12 replacement therapy (26)

Ceruloplasmin: macromolecular assemblies with iron-containing acute phase proteins

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Bickford PC, Tan J, Shytle RD, Sanberg CD, El-Badri N, Sanberg PR