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Many individuals report significant improvement in daily energy, sharper concentration, reduced inflammation, and more consistent mood and sleep patterns

As a result, reviewers generally describe these findings as suggestive rather than definitive

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Pablo Rivera-Fuentes reports financial support was provided by Swiss National Science Foundation.

Stites W, Wang L, Gatlin DM III

Therefore, a combination of multiple strategies such as HFD+fructose and CD+HFD is widely employed to induce insulin resistance, dyslipidemia, ER stress, fibrosis and NASH (111)