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Neuroinflammation is another significant mechanism in many neurodegenerative diseases and is often associated with persistent activation of microglia

2.5 Altered autophagy mechanism (and role of GBA1 gene) Autophagy is a process that in normal conditions maintains cellular balance by recycling proteins and organelles, and acts as an adaptive mechanism that helps cells survive under stressful conditions

Astrocytes actively influence pathogenesis through functional receptors and the release of signaling molecules

Common medications including acetaminophen, statins, and certain antibiotics significantly deplete glutathione reserves during their hepatic processing