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PI3K inhibitors, such as 3-methyladenine (3-MA), wortmannin, and LY294002, target autophagy by inhibiting Vps34, a component of class III PI3K, thereby blocking the formation of autophagosomes [96]

Three hydrophobic residues in AAGABs CTDF262, F266, and L269interact with the 5 and 7 helices of the subunit (fig

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Finally, local inflammatory activation of immune cells has a pivotal role in developing insulin resistance in the liver, adipose tissue and muscle (100, 165, 237)