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Pituitary 20 , 149153 (2017)

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70 The European Medicines Agencys Pharmacovigilance Risk Assessment committee recommended risk minimization measures (RMM) for flupirtine (use only after other analgesics were trialled, patients restricted to up to two week-long treatments, with weekly LFT) due to concern of rare serious liver injury associated with long-term use of flupirtine

J Ren Nutr 26:396400 Rossi M, Campbell KL, Johnson DW, Stanton T, Vesey DA, Coombes JS, Weston KS, Hawley CM, McWhinney BC, Ungerer JPJ, Isbel N (2014) Protein-bound uremic toxins, inflammation and oxidative stress: a cross-sectional study in stage 34 chronic kidney disease

Additional symptoms and comorbidities, such as pain (e.g., migraines, neuropathy) and mast cell activation syndrome (MCAS), are also prevalent in both conditions