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A prospective, placebo-controlled, randomized, single-blind phase II trial was conducted in a multidisciplinary university hospitals ICU where two groups of patients with systemic inflammatory response syndrome aged more than 18 years were randomized to receive either placebo or intravenous Se as a bolus-loading dosage of 2000 g Se followed by a continuous infusion of 1600 g Se per day for ten days, the study revealed that Se supplementation improved illness severity, and reduces the risk of VAP [90]

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Several pre-clinical in vitro and in vivo studies, randomized, double-blind, placebo-controlled trials, and subsequent systematic reviews and meta-analyses demonstrate ALAs potential in preventing or delaying the onset of diabetic complications, namely diabetic peripheral neuropathy (DPN) [15,16,17]

[,] Advance cirrhosis or acute liver failure induces marked renal dysfunction characterized by reducing renal blood flow and glomerular filtration rate (GFR), and this has been referred to as hepatorenal syndrome (HRS). [,] Conventionally, HRS occurs in two different clinical patterns, type 1 HRS (HRS-1, characterized by abrupt impairment of renal function that often occurs because of a precipitating event) and type 2 HRS (HRS-2, a moderate and stable or slowly progressive renal dysfunction often occurs without an obvious precipitant, and it is associated with refractory ascites)