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Description

J Pediatr 1986

The synthetic mRNA construct of claim 1, wherein the mRNA construct comprises 5' cap m7GpppGm, a 5' UTR of A1G AT1G58420 (SEQ ID NO: 10), a Kozak sequence (SEQ ID NO: 121), a coding sequence encoding human coagulation factor IX (F9), one 3' UTR of human alpha globin (hAG) (SEQ ID NO: 81), and a poly(A) tail