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Unlike cosmetic whitening creams, clinical protocols often rely on antioxidant therapies that influence the biological pathways responsible for pigmentation

For those with a B12 deficiency, the initial boost may be more pronounced, and regular maintenance injections may be needed every one to three months to sustain adequate levels

Retracted article : interactions between th1 cells and tregs affect regulation of hepatic fibrosis in biliary atresia through the ifn-/stat1 pathway

Glossary CVDs cardiovascular diseases PH pulmonary hypertension MI myocardial infarction HF heart failure PCI percutaneous coronary intervention mRNA messenger RNA ncRNAs non-coding RNA m6A N6-methyladenosine m1A N1-methyladenosine m5C 5-methylcytosine rRNAs ribosomal RNAs tRNAs transfer RNAs miRNAs micro RNAs lncRNAs long non-coding RNAs 3' UTRs 3'-untranslated regions 5' UTRs 5'-untranslated regions MTC methyltransferase complex METTL3 methyltransferase-like3 METTL14 methyltransferase-like14 WTAP Wilms tumor 1 associated protein ZC3H13 zinc finger CCCH-type containing 13 VIRMA vir like m6A methyltransferase associated RBM15 RNA-binding motif protein 15 FTO fat mass and obesity-associated ALKBH5 alpha-ketoglutarate-dependent dioxygenase alkB homolog 5 ALKBH3 alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 RBPs m6A RNA-binding proteins YTHDF1/2/3 YTH domain-containing family protein 13 YTHDC1/2 YTH domain-containing protein 12 eIF3 eukaryotic initiation factor 3 HNRNP heterologous nuclear ribonucleoprotein IGF2BPs insulin-like growth factor 2 mRNA binding proteins MeRIP-Seq methylated RNA immunoprecipitation and next-generation sequencing GLORI glyoxal and nitrite-mediated deamination of unmethylated adenosine I/R ischemia/reperfusion TFEB transcription factor EB MHTR myosin heavy chain-associated RNA FOXO3 post-transcriptional forkhead box O3 ULK1 Unc-51-like autophagy-activated kinase 1 mTOR mammalian target of the rapamycin LC3BII light chain 3B II H/R hypoxia/reoxygenation PTEN phosphatase and tensin homolog PI3K/Akt/GSK-3 phosphatidylinositol 3-kinase/protein kinase B/glycogen synthase kinase-3 NLRP3 NOD-like receptor protein 3 ASC apoptotic-associated speck-like protein containing a CARD ACS acute coronary syndrome IRF-1 IFN regulatory factor-1 DGCR8 DiGeorge syndrome critical region 8 NEAT1 nuclear paraspeckle assembly transcript 1 TINCR terminal differentiation-induced non-coding RNA NF-B nuclear transcription factor B LPS lipopolysaccharide FOXO1 forkhead box O1 IL-6 interleukin-6 TNF- tumor necrosis factor IL-1 interleukin- STAT1 signal transducer and activator of transcription 1 PPAR- peroxisome proliferator-activated receptor Hmox1 heme oxygenase 1 ROS reactive oxygen species MG53 mitsugumin 53 FSS fluid shear stress ERR estrogen receptor related NFAT5 nuclear factor of activated T cells 5 HIF1 hypoxia-inducible factor 1- NFE2L2 nuclear factor erythroid 2-related factor 2 SR-B1 scavenger receptor B-type 1 KCNQ1OT1 KCNQ1 opposite strand/antisense transcript 1 BACH1 BTB domain and CNC homolog 1 HMEC-1 human microvascular endothelial cell line-1 ACSL4 acyl-CoA synthetase long-chain family member 4 GSH glutathione GPX4 glutathione peroxidase 4 Nog noggin Vangl2 VANGL planar cell polarity protein 2 Trps1 tricho-rhino-phalangeal syndrome 1 PDGF platelet-derived growth factor PASMCs pulmonary artery smooth muscle cells ECs endothelial cells JAK2/STAT3 Janus Kinase 2/Signal Transducer and Activator of Transcription 3 EGFR epidermal growth factor receptor ATF4 activating transcription factor 4 LDH lactate dehydrogenase CK-MB creatine kinase MB AGO2 argonaute 2 GO gene ontology MA maslinic acid TXNIP thioredoxin-interacting protein TPNS total panax notoginseng saponin CLDN1 claudin-1 ZO-1 zonula occludens-1 MCP methionine cyclic peptides TMAO trimethylamine N-oxide DHA dihydroartemisinin VEGF vascular endothelial growth factor NR4A3 nuclear receptor subfamily 4 group A member 3 SREBP-1c sterol regulatory element binding protein-1C SCD-1 stearoyl-CoA desaturase-1 AMPK AMP-activated protein kinase PGC1- PPAR coactivator 1- PM2.5 particulate matter 2.5 AHR aryl hydrocarbon receptor References 1

National research council (US) subcommittee on laboratory animal nutrition, in Nutrient requirements of laboratory animals