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This transition is a hallmark of chronic lung diseases such as CF and advanced stages of COPD, where prolonged P

It has been found to stimulate wound healing through proliferation of keratinocytes, vascular endothelial cells, and fibroblasts, with an effect comparable to that of epidermal growth factor

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therefore, effective antioxidant therapies may give rise to side effects, including increased susceptibility to infections and disruption of ROS-dependent inflammatory signaling