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Biomed Pharmacother 127:110151

Depending on the fluorophores in each experiment, diode lasers of 405, 488, 561, and/or 640 nm were imaged sequentially from longest to shortest wavelength, all with a pinhole size equivalent to 1 airy unit (AU) for each respective wavelength

The conditions used are set out in Table 1

Model 2 (loss-of-rhythm) comprised transcripts that lost their rhythmic expression pattern in cKOt mice

Pregnancy Risk Category X Other currently available non-Biologic DMARDs include: Hydroxychloroquine mechanism : unclear mechanism, but suppresses T-lymphocyte responses to mitogens, decreases leukocyte chemotaxis, inhibits lysosomal enzymes, inhibits DNA & RNA synthesis, & trap free radicals (Furst et al, 2012) Leflunomide mechanism : inhibits dihydroorotate dehydrogenase (DHODH), a key mitochondrial enzyme in de novo pyrimidine synthesis