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This distinction is important because pulse timing, amplitude, and inter-burst recovery intervals each influence receptor responsiveness and downstream signaling behavior

5.2E+9 vs 1.22E+10, p=0.008 respectively) although in serum the results were reversed (higher number of copies in HC group) but only at +the day +21 the difference was significant (mean 20529 vs 677, p=0.005)

Khanmohammadi and Rezaei, 2021

Established indirect modulators of GPX4

Neurobiol Dis 94:169178 Miotto G, Rossetto M, Di Paolo ML, Orian L, Venerando R, Roveri A et al (2020) Insight into the mechanism of ferroptosis inhibition by ferrostatin-1