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Key animal studies (especially in Syrian hamsters, and ideally with hamster-derived CP for matched antibody Fc regions) and human clinical safety and efficacy results for CP are now emerging contemporaneously

2005 May;94(5):642-8

On the other hand, the cell-specific ZnT8-null mice displayed impaired morphology of -cell granules and insulin processing as well as reduced first phase insulin secretion 93

Peroxisome-proliferator-activated receptor-gamma (PPAR) activation protects neurons from NMDA excitotoxicity

In PET imaging of patients with traumatic brain injury, an increased [ 11 C] SL25.1188 uptake was observed in the prefrontal and cortical brain regions compared with controls, and this increase showed an inverse correlation with performance on the Trail Making Test, reflecting reduced psychomotor and processing speed 371