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It is characterized by an initial inflammatory phase during which the immune cells infiltrate the liver to clear the pathogens and dead hepatocytes and promote tissue repair

The mean change in body weight from baseline to week 104 was 15.2% in the semaglutide group ( n = 152) versus 2.6% with placebo ( n = 152), for an estimated treatment difference of 12.6 %-points (95% confidence interval, 15.3 to 9.8

The anti-inflammatory effects appear to be additive, with combined treatment protocols showing greater reductions in inflammatory markers than single-peptide protocols