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By interfering with the mechanisms that support the growth of cancer cells, these inhibitors may be able to stop the growth of tumors and treat metabolic and neurological conditions

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However, even in the absence of specific signs or symptoms of connective tissue diseases, serological autoimmune tests should be performed in all patients.2 In fact, positive anti-nuclear antibodies or rheumatoid factor can be detected in up to 20% of IPF cases.3 The presence of serum specific IgG against the antigens that can most often cause hypersensitivity pneumonitis should be assessed systematically, since its clinical manifestations are occasionally similar to those of IPF

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Drug Discov Today Dis Models (2009) 6:415