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In this process, TMAO activated the NLRP3 inflammasome and NF- signaling pathway (58)

Studies have suggested that disrupted lipid metabolism and suppressed mitochondrial FAO contribute to the pathophysiology of granulomatous lung disease (Huizar et al., 2013

In target tissues, such as the liver and the brain, T 4 (the most abundant circulating thyroid hormone) can be converted to T 3 by selenium-containing enzymes known as iodothyronine deiodinases (DIOs) ( Figure 1