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It has been suggested that the mechanisms of negative changes in gene expression in the liver of broiler chickens after Lactobacillus -based synbiotic injections are probably related to changes in DNA methylation patterns and miRNA activity (147, 149)

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This metabolic imbalance further activates inflammatory pathways like NF-B and fibrotic factors such as TGF-, accelerating glomerulosclerosis and tubulointerstitial injury ( + precursors like nicotinamide mononucleotide (NMN) significantly restores SIRT1 activity, ameliorating proteinuria and renal pathology in db/db mice (Yasuda et al., 2021)